Tafluprost

CAS No:
209860-87-7

Molecular Formula：

C25H34F2O5

Molecular Weight：

452.53

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

Synonyms:

(5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid, 1-methylethyl ester
1O6WQ6T7G3
9868491
CHEMBL1201832
CHEBI:66899
MFCD18252610

IUPAC Name:

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate

InChIKey:

WSNODXPBBALQOF-VEJSHDCNSA-N

InChI:

InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1

SMILES:

CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(COC2=CC=CC=C2)(F)F)O)O

Download Product Documents

Missing docs? Contact support.

Tafluprost-cas-209860-87-7-SDS Tafluprost-cas-209860-87-7-COA Tafluprost-cas-209860-87-7_TDS

Request a Quote

Technical Data

Appearance	pale yellow to colorless Oil
Identification	NMR HPLC
Optical Rotation(C=0.5 ethanol)	+19.0° ~ +23°
Water	≤ 1.0%
Related substances	Tafluprost acid≤ 0.3% 5,6-trans isomer ≤ 0.5 % Any unspecified impurity:≤0.1 % Total impurities：≤2.0 %
Residue Solvent	n-Hexane：≤0.029% Isopropanol：≤0.5% Methyl tert-butyl ether：≤0.5% N,N-Dimethylformamide≤ 0.088%
Purity by HPLC	≥98%

Description

Tafluprost (MK2452, AFP-168) is a selective prostaglandin F (FP) receptor agonist that effectively lowers intraocular pressure (IOP) in preclinical models. In studies using normotensive and glaucomatous rabbits and monkeys, topical administration of tafluprost reduced IOP by 25–35%, demonstrating dose-dependent ocular hypotensive activity. It enhanced uveoscleral outflow with high receptor selectivity and minimal off-target effects, while showing efficient corneal penetration and sustained ocular residence. Pharmacokinetic analyses indicated low systemic exposure, reducing potential side effects. These findings support tafluprost’s potential as a safe and effective therapy for glaucoma and ocular hypertension, providing sustained IOP reduction and protection against optic nerve damage.

Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn²⁺-mTOR pathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma.

Safety Information

GHS

Pictogram:

GHS08 GHS07

Signal Word:

Danger

Hazard Statements:

H302 Harmful if swallowed
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
H370 Causes damage to organs
H372 Causes damage to organs through prolonged or repeated exposure
H413 May cause long lasting harmful effects to aquatic life

Precautionary Statements:

P264 Wash … thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response
P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, ifpresent and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P308+P316 IF exposed or concerned: Get emergency medical help immediately.
P321 Specific treatment (see … on this label).
P319 Get medical help if you feel unwell.
Storage
P405 Store locked up.
Disposal
P501 Dispose of contents/container to an appropriate treatment and disposal
facility in accordancewithapplicable laws and regulations,
and product characteristics at time of disposal.