(-)-Corey lactone 4-phenylbenzoate alcohol
CAS No:
31752-99-5
Molecular Formula：
C21H20O5
Molecular Weight：
352.38
Storage:
Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.
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Technical Data
| Appearance | White to almost white powder |
|---|---|
| Solubility | Soluble in chloroform,ethyl |
| Specific rotation(alpha) | -89° to -83°(20℃,C=1,CHCI3) |
| Melting Point | 129℃ to 134℃ |
| Loss on drying | ≤1.0% |
| E.E value | ≥99.9% |
| Assay | 98%-102% |
Description
Key intermediate for prostaglandin synthesis: It is the chiral intermediate for the synthesis of the prostaglandin PGF2α drug.
Safety Information
GHS
Pictogram:
Signal Word:
Warning
Hazard Statements:
H302 Harmful if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary Statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
References
1.Synthesis and gastric antisecretory properties of allenic 16-phenoxy-omega-tetranor prostaglandin E analogs. | Carpio, H., et al. 1987. Prostaglandins. 33: 169-80. PMID: 3588969
2.Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents. | Resul, B., et al. 1993. J Med Chem. 36: 243-8. PMID: 8423596
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