Norbimatoprost

CAS No:
155206-01-2

Molecular Formula：

C24H35NO4

Molecular Weight：

401.54

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

Synonyms:

17- Phenyl Trinor Prostaglandin F2α Methyl Amide

IUPAC Name:

(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-N-methylhept-5-enamide

InChIKey:

UWIWNJFBNIMMGY-FDBOBMRISA-N

InChI:

InChI=1S/C24H35NO4/c1-25-24(29)12-8-3-2-7-11-20-21(23(28)17-22(20)27)16-15-19(26)14-13-18-9-5-4-6-10-18/h2,4-7,9-10,15-16,19-23,26-28H,3,8,11-14,17H2,1H3,(H,25,29)/b7-2-,16-15+/t19-,20+,21+,22-,23+/m0/s1

SMILES:

CNC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/[C@H](CCC2=CC=CC=C2)O)O)O

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Technical Data

Appearance	Colorless or light yellow oil
Identification(HPLC)	RT of sample should match with standard in the Related substances
Solubility	Freely soluble in methanol, ethanol, ethyl acetate; practically insoluble in water
Water content	≤ 1.0%
15-epimer	≤0.2%
5,6-trans isomer	≤0.2%
Other max single impurity	≤0.1%
Total impurities	≤2.0%
Residue solvents	n-Hexane≤0.029% Ethanol≤0.5% Methanol≤0.3% Toluene ≤0.089% Tetrahydrofuran≤0.072% Ethyl acetate≤0.5% Dichloromethane ≤0.06%
Purity	≥98.0%

Description

17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding.

Safety Information

GHS

Pictogram:

GHS02 GHS07

Signal Word:

Danger

Hazard Statements:

H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.

Precautionary Statements:

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources.
No smoking.
P233 Keep container tightly closed.
P240 Ground / bond container and receiving equipment.
P241 Use explosion-proof [electrical/ventilating/lighting] equipment.
P242 Use non-sparking tools.
P243 Take action to prevent static discharge.
P264 Wash thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing
protection.
P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with
water [or shower].
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P337+P313 If eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use CO2, powder or water spray to extinguish.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.

References

[1]. Balapure AK, et al. Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2 alpha receptor. Implications for development of a photoaffinity probe. Biochem Pharmacol. 1989 Jul 15;38(14):2375-81.

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