Latanoprost

CAS No:
130209-82-4

Molecular Formula：

C26H40O5

Molecular Weight：

432.59

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

Synonyms:

17-Phenyl-13,14-dihydro trinor prostaglandin F2α isopropyl ester
Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
6Z5B6HVF6O
8S5FB3XXG8
CHEBI:6384
5311221
CHEMBL1051
MFCD00216074

IUPAC Name:

propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate

InChIKey:

GGXICVAJURFBLW-CEYXHVGTSA-N

InChI:

InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1

SMILES:

CC(C)OC(=O)CCC/C=C\C[C@H]1[C@H](C[C@H]([C@@H]1CC[C@H](CCC2=CC=CC=C2)O)O)O

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Technical Data

Appearance	colorless or light yellow Oil
Identification	A： IR B： The retention time of the major peak in the chromatogram of the sample corresponds to that of the standard solution, as obtained in the assay.
Solubility	Freely soluble in Isopropanoll and methanol
Residue on ignition	≤0.5%
Specific Rotation	+ 31° ~ + 38°
Water	≤ 2.0 %
Related substances	Isopropyl diphenylphosphorylpentanoate ≤ 0.1% Latanoprost related Compound B ≤ 0.5% Latanoprost related Compound A ≤ 3.5% Any other impurity： ≤ 0.1% Total impurities：≤ 0.5% LIMIT OF LATANOPROST RELATED COMPOUND E≤ 0.2%
Residue Solvent	n-Hexane：≤ 0.029% Ethanol： ≤ 0.5% Methanol：≤ 0.3% Isopropanol ≤ 0.5
Assay	94.0%~102%(calculated on the anhydrous and sol-vent-free basis)

Description

Latanoprost (PHXA41) is a prostaglandin F2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea.

Safety Information

GHS

Pictogram:

GHS06 GHS08

Signal Word:

Danger

Hazard Statements:

H300: Fatal if swallowed.
H361: Suspected of damaging fertility or the unborn child.

Precautionary Statements:

GHS Precaution Phrases:
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P264: Wash {hands} thoroughly after handling.
P280: Wear {protective gloves/protective clothing/eye protection/face protection}.
GHS Response Phrases:
P301+310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+313: IF exposed or concerned: Get medical attention/advice.
P330: Rinse mouth.
GHS Storage and Disposal Phrases:
Please refer to Section 7 for Storage and Section 13 for Disposal information.