Latanoprost

CAS No:
130209-82-4

Molecular Formula：

C26H40O5

Molecular Weight：

432.59

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

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Technical Data

Appearance	colorless or light yellow Oil
Identification	A： IR B： The retention time of the major peak in the chromatogram of the sample corresponds to that of the standard solution, as obtained in the assay.
Solubility	Freely soluble in Isopropanoll and methanol
Residue on ignition	≤0.5%
Specific Rotation	+ 31° ~ + 38°
Water	≤ 2.0 %
Related substances	Isopropyl diphenylphosphorylpentanoate ≤ 0.1% Latanoprost related Compound B ≤ 0.5% Latanoprost related Compound A ≤ 3.5% Any other impurity： ≤ 0.1% Total impurities：≤ 0.5% LIMIT OF LATANOPROST RELATED COMPOUND E≤ 0.2%
Residue Solvent	n-Hexane：≤ 0.029% Ethanol： ≤ 0.5% Methanol：≤ 0.3% Isopropanol ≤ 0.5
Assay	94.0%~102%(calculated on the anhydrous and sol-vent-free basis)

Description

Latanoprost (PHXA41) is a prostaglandin F2α analogue and can be used for glaucoma research. Latanoprost can effectively pass through cornea and be hydrolyzed by esterase to latanoprost acid. latanoprost acid is an F-prostaglandin (FP) receptor agonist, and can effectively reduce intraocular pressure (IOP) by increasing the outflow of aqueous humor through uvea.

Safety Information

GHS

Pictogram:

GHS08 GHS07 GHS02

Signal Word:

Danger

Hazard Statements:

H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H361 Suspected of damaging fertility or the unborn child.
H336 May cause drowsiness or dizziness.

Precautionary Statements:

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapors/spray
P264 Wash thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with
water/shower.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P312 Call a poison center/doctor if you feel unwell.
P337+P313 If eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use CO2, powder or water spray to extinguish.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.

References

[1]. Pauly A, et al. In vitro and in vivo comparative toxicological study of a new preservative-free latanoprost formulation. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8172-80.

[2]. Zheng J, et al. Latanoprost promotes neurite outgrowth in differentiated RGC-5 cells via the PI3K-Akt-mTOR signaling pathway. Cell Mol Neurobiol. 2011 May;31(4):597-604.

[3]. Tsai S, et al. The effect of topical latanoprost on anterior segment anatomic relationships in normal dogs. Vet Ophthalmol. 2013 Sep;16(5):370-6.

[4]. Ooi YH, et al. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5259-65.

[5]. B’Ann True Gabelt, et al. Prostaglandin Subtype-Selective and Non-Selective IOP-Lowering Comparison in Monkeys.

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