Gs-441524

CAS No:

1191237-69-0

Molecular Formula：

C12H13N5O4

Molecular Weight：

291.26

Synonyms:
  • Remdesivir metabolite
  • GS441524
  • GS 441524
  • (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile
  • 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
  • Remdesivir parent nucleoside
  • Remdesivir intermediate
  • 1BQK176DT6
  • 44468216
  • CHEBI:147281

IUPAC Name:

(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile

InChIKey:

BRDWIEOJOWJCLU-LTGWCKQJSA-N

InChI:

InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1

SMILES:

C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)CO)O)O)C#N)N

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Technical Data

Description

GS-441524 is an adenosine nucleotide analog antiviral, similar to [remdesivir]. This molecule was patented in 2009. In vitro studies of GS-441524 have determined it has a higher EC50 than remdesivir against a number of viruses, meaning GS-441524 is less potent. GS-441524 continues to be studied in the treatment of Feline Infectious Peritonitis Virus, a coronavirus that only infects cats.

Safety Information

GHS

Pictogram:

GHS07GHS05GHS08

Signal Word:

Danger

Hazard Statements:

H315 : Causes skin irritation
H317 : May cause an allergic skin reaction
H318 : Causes serious eye damage
H334 : May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335 : May cause respiratory irritation
H341 : Suspected of causing genetic defects
H361 : Suspected of damaging fertility or the unborn child
H371 : May cause damage to organs

Precautionary Statements:

Prevention
P203: Obtain, read and follow all safety instructions before use.
P233: Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P264: Wash thoroughly after handling.
P264+P265: Wash thoroughly after handling. Do not touch eyes.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should
not be allowed out of the workplace.
P280: Wear protective gloves/
protective clothing/eye protection/face protection.
P284: [In case of inadequate ventilation] wear respiratory protection.

Response
P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P354+P338: IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue rinsing.
P308+P316: IF exposed or concerned: Get emergency medical attention immediately.
P317: Get medical help.
P318: IF exposed or concerned, get medical advice/attention.
P319: Get medical advice/attention if you feel unwell.
P332+P317: If skin irritation occurs: Get medical help.
P333+P317: If skin irritation or rash occurs: Get medical help.
P342+P316: If experiencing respiratory symptoms: Get emergency medical attention immediately.
P362+P364: Take off contaminated clothing and wash it before reuse.

Storage
P403: Store in a well-ventilated place.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P405: Store locked up.

Disposal
P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

References

Impact of remdesivir modifications on human HINT1 binding – A structural and functional study in the remdesivir activation pathway；Publication Name: Structure (London, England : 1993)；Publication Date: 2026-05-25；PMID: 42184828；DOI: 10.1016/j.str.2026.04.015

Efectividad y seguridad de remdesivir y nirmatrelvir-ritonavir en la COVID-19 leve-moderada en los servicios de urgencia hospitalaria españoles；Publication Name: Medicina Clínica；Publication Date: 2025-08；PMID: 40412101；DOI: 10.1016/j.medcli.2025.106912

Successful treatment of prolonged COVID-19 with remdesivir and nirmatrelvir/ritonavir in a patient with a history of diffuse large B-cell lymphoma: a case report；Publication Name: Journal of the Egyptian National Cancer Institute；Publication Date: 2025-06-30；PMID: 40583098；DOI: 10.1186/s43046-025-00291-1

Eco-friendly spectrofluorimetric determination of remdesivir in the presence of its metabolite in human plasma for therapeutic monitoring in COVID-19 patients；Publication Name: Scientific Reports；Publication Date: 2025-06-23；PMID: 40550830；DOI: 10.1038/s41598-025-05198-4

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?；Publication Name: Viruses；Publication Date: 2025-06-10；PMID: 40573427；DOI: 10.3390/v17060836

Population Pharmacokinetic Modelling of Remdesivir and Its Metabolite GS-441524 in Hospitalised Patients with COVID-19；Publication Name: Clinical Pharmacokinetics；Publication Date: 2025-04-22；PMID: 40261493；DOI: 10.1007/s40262-025-01496-2

High‐dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir, GS‐441524 and adjunctive mefloquine: 46 cases (2023)；Publication Name: The Journal of small animal practice；Publication Date: 2025-04-18；PMID: 40251466；DOI: 10.1111/jsap.13869

Treatment of feline infectious peritonitis in cats with molnupiravir: clinical observations and outcomes for 54 cases；Publication Name: Australian Veterinary Journal；Publication Date: 2025-04-15；PMID: 40234239；DOI: 10.1111/avj.13433

Pharmacokinetics of GS‐441524 following intravenous remdesivir in six cats and results of therapeutic drug monitoring during treatment of feline infectious peritonitis: 22 cases (2021–2024)；Publication Name: The Journal of small animal practice；Publication Date: 2025-03-17；PMID: 40097914；DOI: 10.1111/jsap.13849

Remdesivir is active in vitro against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase；Publication Name: Infectious diseases (London, England)；Publication Date: 2025-02-20；PMID: 39973341；DOI: 10.1080/23744235.2025.2468510

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