Cloprostenol

CAS No:
40665-92-7

Molecular Formula：

C22H29ClO6

Molecular Weight：

424.92

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

Synonyms:

CLOPROSTENOL
Cloprostenolum
4208238832
52EJR3Y9IN
MFCD00217060
(+)-Cloprostenol
CHEMBL37853
GTPL1894

IUPAC Name:

(Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid

InChIKey:

VJGGHXVGBSZVMZ-QIZQQNKQSA-N

InChI:

InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1

SMILES:

C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC(=CC=C2)Cl)O)C/C=C\CCCC(=O)O)O

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Technical Data

Description	White power
Identification	HNMR HPLC IR
Water conten	≤3.0 %
15S-isomer	≤1.0 %
5,6-(trans)-isomer	≤1.0 %
Any other impurities	≤0.5 %
Total impurities	≤2.0 %
Puirty	> 98.0 %

Description

Cloprostenol is a prostaglandin F2α (PGF2α (HY-12956)) analogue. Cloprostenol can induce luteolysis. Cloprostenol can be used for open-cervix pyometra research

Safety Information

GHS

Pictogram:

GHS07 GHS08

Signal Word:

Danger

Hazard Statements:

H302: Harmful if swallowed
H317: May cause an allergic skin reaction
H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled
H360: May damage fertility or the unborn child

Precautionary Statements:

P203: Obtain, read and follow all safety instructions before use.
P233: Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P264: Wash hands thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P271: Use only outdoors or in a well-ventilated area.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection/
P284: [In case of inadequate ventilation] wear respiratory protection.
P301+P317: IF SWALLOWED: Get medical help.
P302+P352: IF ON SKIN: Wash with plenty of water/
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P318: If exposed or concerned, get medical advice.
P330: Rinse mouth.
P333+P317: If skin irritation or rash occurs: Get medical help.
P342+P316: If experiencing respiratory symptoms: Get emergency medical help immediately.
P362+P364: Take off contaminated clothing and wash it before reuse.
P403: Store in a well-ventilated place.
P405: Store locked up.

References

[1]. Summers PM, et al. Cloprostenol-induced luteolysis in the marmoset monkey (Callithrix jacchus). J Reprod Fertil. 1985 Jan;73(1):133-8.

[2]. García Mitacek MC, et al. Cloprostenol treatment of feline open-cervix pyometra. J Feline Med Surg. 2014 Feb;16(2):177-9.

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