Alprostadil;PGE1

CAS No:
745-65-3

Molecular Formula：

C20H34O5

Molecular Weight：

354.48

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

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Technical Data

Appearance	White to off-white crystalline powder
Identification	HPLC retention time of sample complies with that of known sample
Specifific optical rotation	-60.0°~ -70.0°
Water	≤0.5%
Residue on Ignition	≤0.5%
Related Substances	Impurity A ≤1.5% Impurity B ≤ 0.5% Any other impurity ≤ 0.9% Total impurities ≤1.5%
Residual solvents	Ethanol ≤5000ppm Acetone ≤5000ppm Dichloromethane ≤600ppm n-Hexane ≤290ppm Ethyl acetate ≤5000ppm n-Heptane ≤5000ppm
Assay	95.0%~102.5%(anhydrous substance)

Description

Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases.

Safety Information

GHS

Pictogram:

GHS06 GHS08

Signal Word:

Danger

Hazard Statements:

H301 Toxic if swallowed.
H360 May damage fertility or the unborn child.

Precautionary Statements:

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection.
P301+P310 If swallowed: Immediately call a poison center/doctor.
P321 Specific treatment (see on this label).
P330 Rinse mouth.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.

References

1. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

2. Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85.

3. Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction–a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.

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