Dinoprostone;PGE2

CAS No:
363-24-6

Molecular Formula：

C20H32O5

Molecular Weight：

352.47

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

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Technical Data

Appearance	Colorless to yellowish solid
Identification	HNMR HPLC
Specific optical rotation	-82.0°~ -90.0°
Water	≤0.5%
Loss on drying	≤1.0%
Relative substances	5,6-trans-dinoprostone: ≤ 2.0% (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5, 10,13-triene-1-oic acid: ≤1.0% (5Z,13E,15S)-15-hydroxy-9-oxoprosta-5, 8(12),13-trien-1-oic acid: ≤1.0% Total other impurity ≤ 1.0%
Relative Solvents	ethyl acetate: ≤0.5%
Assay	97.0%~103.0%

Description

Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

Safety Information

GHS

Pictogram:

GHS07 GHS08

Signal Word:

Danger

Hazard Statements:

H302 Harmful if swallowed.
H360 May damage fertility or the unborn child.

Precautionary Statements:

P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection.
P301+P312 If swallowed: Call a poison center/doctor if you feel unwell.
P330 Rinse mouth.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.

References

1. Chouaib S, et al. The mechanisms of inhibition of human IL 2 production. II. PGE2 induction of suppressor T lymphocytes. J Immunol. 1984 Apr;132(4):1851-7.

2. Fernandez-Repollet E, et al. In vivo effects of prostaglandin E2 and arachidonic acid on phagocytosis of fluorescent methacrylate microbeads by rat peritoneal macrophages. J Histochem Cytochem. 1982 May;30(5):466-70.

3. Haylor J, et al. Renal vasodilator activity of prostaglandin E2 in the rat anaesthetized with pentobarbitone. Br J Pharmacol. 1982 May;76(1):131-7.

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