Travoprost Acid;(+)-Fluprostenol
CAS No:
54276-17-4
Molecular Formula：
C23H29F3O6
Molecular Weight：
458.47
Storage:
Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.
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Technical Data
| Appearance | Colorless to yellowish viscous oily liquid |
|---|---|
| Identification | HNMR HPLC |
| Puirty | ≥97% |
Description
(+)-Fluprostenol is the optically active enantiomer of fluprostenol (sc-201336). It is a metabolically stable analog of PGF2α and a potent FP prostanoid receptor (PGF2αR) agonist. The expected potency of (+)-fluprostenol is twice that of (±)-fluprostenol for PGF2α binding to human and rat FP receptors. (+)-Fluprostenol is an effective inhibitor of rat adipose precursor differentiation in primary cultures.
Safety Information
GHS
Pictogram:
Signal Word:
Danger
Hazard Statements:
H225 Highly flammable liquid and vapor.
H300+H330 Fatal if swallowed or if inhaled.
H311 Toxic in contact with skin.
H319 Causes serious eye irritation.
H370 Causes damage to organs.
H372 Causes damage to organs through prolonged or repeated exposure.
Precautionary Statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P260 Do not breathe dust/fume/gas/mist/vapors/spray.
P264 Wash thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 [In case of inadequate ventilation] wear respiratory protection.
P301+P310 If swallowed: Immediately call a poison center/doctor.
P330 Rinse mouth.
P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with
water/shower.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P307+P311 IF exposed: Call a POISON CENTER or doctor/physician.
P312 Call a poison center/doctor if you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P320 Specific treatment is urgent (see on this label).
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P337+P313 If eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use CO2, powder or water spray to extinguish.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.
References
Katsuyama M, et al. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. J Biol Chem. 2002 Apr 19;277(16):13438-42. PMID: 11832489.
McCue BA, et al. Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS. J Pharm Biomed Anal. 2002 Apr 15;28(2):199-208. PMID: 11929662.
Józefowski S, et al. Exogenous but not endogenous prostanoids regulate cytokine secretion from murine bone marrow dendritic cells: EP2, DP, and IP but not EP1, EP3, and FP prostanoid receptors are involved. Int Immunopharmacol. 2003 Jun;3(6):865-78. PMID: 12781703.
Dukes M, et al. Potent luteolytic agents related to prostaglandin F2alpha. Nature. 1974 Jul 26;250(5464):330-1. PMID: 4853720.
Lake S, et al. Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. FEBS Lett. 1994 Dec 5;355(3):317-25. PMID: 7988697.
Abramovitz M, et al. Cloning and expression of a cDNA for the human prostanoid FP receptor. J Biol Chem. 1994 Jan 28;269(4):2632-6. PMID: 8300593.
Serrero G, Lepak NM. Prostaglandin F2alpha receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun. 1997 Apr 7;233(1):200-2. PMID: 9144422.
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