Dinoprost tromethamine

CAS No:

38562-01-5

Molecular Formula:

C24H45NO8

Molecular Weight:

475.62

Storage:

Store in a tightly closed container in a cool, dry,Protect from moisture and direct sunlight.

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Technical Data

Appearance

White or off- white powder

Identification

The IR spectrum of the sample exhibits maximun only at the same wavelength as that similar preparation of USP Dinoprost Tromethamine RS

Solubility

Very soluble in water,freely soluble in ethanol(96%),practically insoluble in acetonitrile

Optical rotation

+19°~ +26°

Loss on drying

≤ 1.0%

Residue on ignition

≤0.5 %

Water

≤1.0 %

Residual solvents

Ethyl acetate: ≤ 5000ppm
Acetone: ≤5000ppm
Acetontrile: ≤ 410ppm
Ethanol: ≤5000ppm
Methanol: ≤3000ppm
Terahydrofuran : ≤720ppm

Chromatographic Purity

Impurity A: ≤2.0%
Impurity B: ≤ 1.5%
Any unspecified impurity: ≤ 0.10%
Total other impurities: ≤ 2.0%

Description

Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.

Safety Information

GHS

Pictogram:

GHS08GHS07

Signal Word:

Danger

Hazard Statements:

H302 Harmful if swallowed.
H360 May damage fertility or the unborn child.

Precautionary Statements:

Prevention:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have
been read and understood.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this
product.
P280 Wear protective gloves/ protective clothing/ eye
protection/ face protection.
Response:
P301 + P312 + P330 IF SWALLOWED: Call a POISON
CENTER/ doctor if you feel unwell. Rinse mouth.
P308 + P313 IF exposed or concerned: Get medical
advice/ attention.
Storage:
P405 Store locked up.
Disposal:
P501 Dispose of contents/ container to an approved waste disposal plant.

References

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