Lubiprostone

CAS No:
136790-76-6

Molecular Formula：

C20H32F2O5

Molecular Weight：

390.46

Storage:

Store in a tightly closed container in a cool, dry，Protect from moisture and direct sunlight.

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Technical Data

Appearance	White or off-white crystalline powder
Identification	HNMR HPLC
Specific rotation	[α]20D: – 42.0º ~ – 48.0º
Water	< 0.5 %
Limit of related substance	Lubiprostone A≤0.1 %
Any unknown impurity	≤0.1 %
Total impurities	≤1.0 %
Residue on Ignition	≤ 0.1%
Residue Solvent	Pentane ≤5000ppm Ethyl acetate≤1000ppm Acetonitrile≤400ppm Diisopropyl ether≤500ppm Hexane≤150ppm Dichloromethane≤500ppm
Assay	98.00 % to 102.00 % (on anhydrous substance)

Description

Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research.

Safety Information

GHS

Pictogram:

GHS07 GHS02

Signal Word:

Danger

Hazard Statements:

H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness

Precautionary Statements:

P210 Keep away from heat/sparks/open flames/hot surfaces. – No smoking.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapors/spray
P264 Wash thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 If on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with
water/shower.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P305+P351+P338 If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing.
P312 Call a poison center/doctor if you feel unwell.
P337+P313 If eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use CO2, powder or water spray to extinguish.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/national/international
regulations.

References

1. Ao M, et al., Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig Dis Sci. 2011 Feb;56(2):339-51.

2. Kim MY, et al., Lubiprostone significantly represses fatty liver diseases via induction of mucin and HDL release in mice. Life Sci. 2022 Dec 15;311(Pt A):121176.

3. Hayashi S, et al., Lubiprostone prevents nonsteroidal anti-inflammatory drug-induced small intestinal damage by suppressing the expression of inflammatory mediators via EP4 receptors. J Pharmacol Exp Ther. 2014 Jun;349(3):470-9.

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